Animal models which include mice and rats are frequently used in the study of inflammatory, neurodegenerative, and neoplastic and vascular diseases (Denic, 2011). Small animal models of human diseases are currently needed and have become an important tool for biomedical research. Animal studies as models for human diseases provided important understandings into the aetiology of diseases and can be used to provide improvement on the current therapeutic strategies (Lo, 2017). In order to test the efficacy of experimental therapeutics and disease pathogenesis, detailed phenotypic characterisation is really important in animal models and mechanistic studies (Denic, 2011). Improvement in diagnostic accuracy, determination of prognosis, and selection of optimum treatment allowed for the more advanced imaging methods (Glodek et al., 2016). Magnetic Resonance Imaging (MRI), considered one of the most versatile non-invasive imaging modalities and as a transitional stage for in vitro and in vivo studies (Glodek et al., 2016).